25 Jul 16

Despite these exciting developments, scientists still have only a very basic understanding of how cells are pluripotent. Jose Silva, who led the Cambridge research with his colleague Dr Jennifer Nichols, ‘Exactly how pluripotency is a mystery is create create an efficient, safe and reliable ways of generating these cells for medical applications, we need to understand the process, our research provides additional clues as to how it occurs ‘.

Austin Smith, one of the most important post researcher , is a Medical Research Council Professor.. This study notes Wellcome Trust Wellcome Trust, the Biotechnology and Biological Sciences Research Council and the EC Framework Programme 7 project Euro system was supported. The paper, Nanog is the Gateway to the pluripotent Ground State , the 21st August issue of Cell by Jose Silva., Jennifer Nichols et al Nanog was isolated in 2003 by two groups For more information, see the following publications:. Chambers et al, Functional expression cloning of Nanog one factor supporting pluripotency in embryonic stem cells, Cell , doi: 10.1016/S0092-8674 00392-1 Mastsui et al, 1016/S0092-8674 00393-33) This work was supported by the Wellcome Trust, the Biotechnology and Biological Sciences Research support: the homeoprotein Nanog is responsible for the maintenance of pluripotency in mouse epiblast and ES cells, Cell , doi require Council and the EC Framework Programme 7 project Euro system.In the current study, Sugden and colleague for 20 years, Wolfgang Hammerschmidt, now is the German Research for Environment and Health, designed to gene controlling on different segments of of 640 amino acids that the mutation is is based EBNA – is a protein having a coding proteins from about 100 EBV. Then human B – cells infected with various mutant EBVs implementing EBNA-1s. With a drug that a 25 amino acid segment inside EBNA-1 is responsible for regulation of viral gene transcriptional the first step in the process, in which a gene coded info was high in RNA and then converted to protein.

‘If we identify this protein, it is easier for ourselves assays to screening of small molecules, which develop with said protein competing upon binding to EBNA-1,’Sugden says. ‘Due to the prevention of cell protein at the binding to the segment be EBNA – 1 Got in a position to his function and the tumor cells , it contributes to die.’.