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Cipher announces completion of patient enrolment in CIP-ISOTRETINOIN Stage III research for nodular acne Cipher Pharmaceuticals Inc. today announced that it offers completed patient enrolment in its Stage III safety research of CIP-ISOTRETINOIN, the Company’s novel, patented formulation of isotretinoin, which can be used in the treating severe, nodular acne.S. Meals and Medication Administration . The scholarly study is a randomized, double-blinded trial evaluating the security profile of CIP-ISOTRETINOIN to an FDA-approved, commercially available isotretinoin product.