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During the Phase II development, TDT reached 067 two orders of magnitude lower plasma terbinafine performed concentrations compared to oral terbinafine in a pharmacokinetic study under the conditions of maximum utilization In contrast, terbinafine levels measured in affected nails three orders of magnitude higher than those reported for oral terbinafine http://cialis20mg-portugal.com/cialis-ou-viagra.html . This illustrates the targeted delivery of terbinafine. Been studies in a Phase II efficacy and safety of patients treated for only 12 weeks with a primary endpoint of mycological cure at 14 weeks and follow up 48 weeks, 90 percent mycological cure rate was observed at 14 weeks. After 48 weeks the mycological cure rate was was 38 percent, though. No active treatment for the previous 36 weeks TDT 067 was well tolerated with negligible systemic exposure and no serious local side effects, confirming the maximal use study findings, suggesting that patients be treated for longer durations, improved improved efficacy.

About Onychomycosis Onychomycosis is a fungal infection, generally of the toenails, that results in thickening, discoloration, splitting of the nails and lifting of the nail from the nail bed. The disease has a high incidence in the general population – estimated as high as 13 percent in the U.S. – particularly in the elderly, with only a small %age of patients who are treated. Current treatment options include both oral and topical medications that are oral therapies with better results. Er, these oral therapies remains a black box warning and carry the risk of systemic side effects, especially hepatoxicity. Disproportionate to the disease, which can be treated This results in a large %age of the condition is not affected, the most effective treatments given.

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