11 Jan 17

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To the first experiments, pre-neoplastic and neoplastic mouse model CPCs in order to to determining when OPN begin role role. Fabrics from those mouse models were stained for OPN expression. OPN expressing had increasing in models of of low-grade PIN, high-grade PIN, adenocarcinoma and metastatic adenocarcinoma of. Transferors prostate gland Tumour contained 3.2 – times higher levels of OPN.

The effect of overexpression OPN been clearly in LNCaP cells, maybe due to the fact that their basal expression of osteopontin was less. PC3 cells have greater basale expressing OPN and said additional sum may not so great at has biological effects in the in the LNCaP cells.